ADC Landscape
Merck / Daiichi
HER3 · EGFR-mutant NSCLC
Phase 3Antibody–Drug Conjugates
Target
HER3
Payload
Deruxtecan (DXd)
Payload class
Topo-I inhibitor
Linker
Cleavable tetrapeptide
Indication
EGFR-mutant NSCLC
Phase
Phase 3
Partner
Merck
Overview
First HER3-directed ADC near approval — targets a resistance pathway in EGFR-mutant lung cancer after TKI failure.
Technology
Merck / Daiichi works in Antibody–Drug Conjugates — A guided missile: an antibody that flies a chemo warhead straight to the tumor.
Read the Antibody–Drug Conjugates brief →Related companies
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AstraZeneca / Daiichi
TROP2
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CD30
Pfizer (Seagen)
Nectin-4
Pfizer (Seagen)
Tissue Factor
Company website / source ↗ Open the interactive map →
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